Speaker
Description
Nuclear Magnetic Resonance methods play a crucial role in the novel, toxicity reduced, high dose-rates radiotherapy technique for cancer treatment, by providing useful information about early radiation effects on biochemical processes occurring in tissues. Metabolic profiling, by identification of biomarkers associated with radiation response, serves as indication of treatment efficiency, which is done using NMR spectroscopy studies. On the other hand, real-time imaging of free-radical formation, by direct experimental methods, is also very important in radiobiology.
This presentation will provide insight into the NMR methods that are used in the context of ELI-NP, containing both metabolic profiling studies of radiation dose-rate effects on cancer and healthy cells, by NMR spectroscopy, and detection studies of free-radical formation during the time course of a chemical reaction, which can be imaged through NMR relaxation measurements of water protons in Earth’s magnetic field, in an open-coil spectrometer.
