Speaker
Description
Radiotherapy is used in combination with other techniques to treat different types of cancer. High dose-rate delivery of radiation, as afforded by high-power laser systems, may improve radiotherapy methods. The aim of high dose-rate 'FLASH' radiation delivery is to spare the healthy tissue, while maintaining at the same time the desired therapeutic effect on tumors. We have established an irradiation setup using secondary radiation (electrons) stemming from the interaction chambers of 100 TW and 1 PW laser beams operating in pulses of 1.5-2 J, 29.5-30 J and 28 fs duration delivered onto a gas target. Variations in metabolite concentrations between control and irradiated samples for U251 Glioblastoma cells (tumoral cell line) and BV-2 Microglia cells (non-tumoral cell line) were measured using high-field Nuclear Magnetic Resonance spectroscopy. The metabolic profiles from the two types of cell lines allow us to assess the effects of FLASH radiation immediately after delivery to cells.
